I D
× COMMENTARYCOVER STORYIN THE NEWSNEWSFRONTS
Optimized Mixing
Improved equipment and controls, as well as continuous mixing, improve…
CHEMENTATOR + Show More BUSINESS NEWSTECHNICAL & PRACTICALFEATURE REPORTFACTS AT YOUR FINGERTIPSTECHNOLOGY PROFILEENVIRONMENTAL MANAGEREQUIPMENT & SERVICESFOCUS
Focus on Analyzers
Raman spectroscopy capability with bioreactor platforms BioPAT Spectro (photo) is…
NEW PRODUCTS + Show More SHOW PREVIEWS
Show Preview-IFAT
IFAT (rescheduled for September 7–11, Munich, Germany; www.ifat.de) is the…

Comment PDF

A new iodine-based catalyst for asymmetric synthesis

By Tetsuo Satoh |

Professor Kazuaki Ishihara and colleagues at Nagoya University (Nagoya, Japan;www.nubio.nagoya-u.ac.jp/indexe.HTM) has discovered an efficient, chiral, salt-based hypervalent iodine catalyst that could replace toxic metal catalysts without generating the waste or explosion risks associated with hypervalent organo-iodine complexes. The researchers took the radical step of swapping iodine bonded to carbon for an iodite (IO2–) or hypoiodite (IO–) anion as the oxidant, which can be generated from iodide (I–) by simple oxidants, such as hydrogen peroxide. The team also coupled the (hypo)iodite with a chiral, quaternary-amine counter ion to solubilize the inorganic iodite in organic solvents and provide a chiral environment to control the geometry of the reaction. In the laboratory, the researchers performed an enantio-selective, oxidative cycloetherification of ketophenols to 2-acyl-2,3-dihydrobenzofuran derivatives — a key structure in several biologically active compounds — catalyzed by in-situ-generated chiral, quaternary-ammonium-(hypo)iodite salts, with hydrogen peroxide as an environmentally benign oxidant (only water and alcohol are generated as byproducts). After recrystallization, an optical purity…
Related Content
This gold catalyst improves CO2 reduction
Researchers from the Korea Advanced Institute of Science and Technology (KAIST; Daejeon; www.kaist.ac.kr) have developed a three-dimensional (3D) hierarchically porous…
Chementator Briefs
Li2CO3 from brine Purities of greater than 99.9% for battery-quality lithium carbonate have been achieved using a proprietary artificial-intelligence-powered crystallization…

Chemical Engineering publishes FREE eletters that bring our original content to our readers in an easily accessible email format about once a week.
Subscribe Now
Improving chemical production processes with IIoT and AI technologies
New filtration technology for highly corrosive media
PTA production: Lowering OPEX without compromising on quality
Sure that zero means zero in your zero-liquid discharge (ZLD) process?
How separation processes profit from Industrial Internet of Things (IIoT) solutions

View More