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Technology Profile: Bio-based Butanediol Production

By Intratec Solutions |

This column is based on “Bio-Butanediol Production from Glucose,” a report published by Intratec. It can be found at: www.intratec.us/analysis/butanediol-production-cost. Butanediol (BDO) refers to all butylene glycol isomers. The most common isomer — 1,4-butanediol — is a versatile intermediate chemical used in the manufacture of plastics, elastic fibers and polyurethanes. Commercial processes for producing bio-based BDO from sugars have emerged in recent years as alternatives to petroleum-derived BDO. This one-page process description outlines the production of BDO by the fermentation of glucose. Figure 1. The process shown here describes the production of butanediol via the fermentation of glucose[/caption]   The process The following paragraphs describe a process for bio-butanediol production from glucose (Figure 1) similar to the process described in patents issued to Genomatica Inc. (San Diego, Calif.; www.genomatica.com). Medium preparation. The preparation of the culture media involves dilution tanks, pumps and sterilizers. The culture media used in the batch and fed-batch phases of pre-fermentation and fermentation are prepared by mixing process water, glucose and nutrients. Fermentation. In the fermentation…
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