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Capsosomes: a new launching platform for delivering drugs where needed

By Paul Grad |

Transport systems that can encapsulate medications for release when and where needed are the subject of much research and development, especially for two potential synthetic vessels: liposomes and multilayered polymer capsules. Both, however, entail limitations. The permeability of polymer capsules, although partly desirable, also makes them unsuitable for providing a protective barrier for small drugs and reagents. On the other hand, small unilamellar liposomes can be susceptible to structural instability and are largely impermeable to their surroundings. To overcome those limitations, a group of researchers from the University of Melbourne (www.unimelb.edu.au) and CSIRO Molecular and Health Technologies (Parkville, Victoria, both Australia) and led by professor Frank Caruso, Dept. of Chemical and Biomolecular Engineering at Melbourne, has developed a method for creating capsosomes — polymer capsules that contain liposomal subcompartments to maximize the benefits offered by both, polymer multilayer capsules and liposomes. The group has shown that capsosomes inherit the structural stability of the polymer capsules, and have a semipermeable nature; and the liposomes are capable of restricting the access of solutes to an encapsulated…
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