Carry Out a Range of Reactions with Contiuous-Flow Synthesis

Raising the reaction temperature achievable with the FlowSyn Continuous Flow Reactor (photo) has considerably widened the scope of reactions that can be performed, according to the manufacturer. Reactions can now be carried out at temperatures up to 260ºC and pressures up to 1,000 psi. High-activation-energy chemistries that may previously have required a catalyst or the use of a microwave reactor are now potential candidates for continuous flow synthesis, with its attendant benefits — better reproducibility and scalability, and fewer problems with unstable intermediates or unexpected exotherms. Other improvements include easier pump priming and refinements to the automated reaction control so that the user can control the amount of pre- and post-plug dispersion phases that are collected with their steady-state reaction product. — Uniqsis, Ltd., Cambridge, U.K.