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Chementator: Chiral synthesis  

By Gerald Ondrey |

Scientists from the Center Biology at University College Dublin (Ireland; edlinks.chemengonline.com/7370-576) and the University of Bologna (Italy; edlinks.chemengonline.com/7370-577) have developed an enzymatic process that can be applied to the synthesis of chiral pharmaceutical intermediates. The researchers use an enzyme called horse liver alcohol dehydrogenase to drive a process known as dynamic kinetic resolution (DKR), which takes advantage of the different reaction rates for forming the R and S enantiomers. The technology has been demonstrated in the laboratory for producing S-ibuprofenol, the active precursor of the anti-inflammatory agent, ibuprofen. Conventional synthesis of the Profin class of pharmaceuticals produces a 50:50 mixture of the two isomers, thus requiring additional separation steps to isolate the active form.   Click here for a full pdf version of the Chementator Section  
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