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Chementator: New chiral compounds

By Chemical Engineering |

BASF AG (Ludwigshafen, Germany; edlinks.chemengonline.com/5827-546) has developed a new process for producing chiral intermediates for pharmaceutical products. Without disclosing any details, BASF says the process is based on dehydrogenase enzymes for making optically active styrene oxides and aliphatic alcohols. The biocatalyst is derived from a microorganism (type not disclosed), and then optimized by the company’s ChiPros technology, whereby evolution is accelerated in the laboratory on the basis of mutation and selection. BASF has also added two new chiral amines to its product portfolio: (R,R)- and (S,S)-bis(1-phenylethyl)amine. The compounds are used for the asymmetric synthesis of non-natural amino acids, and as the starting ingredient for chiral bases.   Click here for a full pdf version of the Chementator Section
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