I D
× COMMENTARYCOVER STORYIN THE NEWSNEWSFRONTSCHEMENTATOR + Show More
Chementator Briefs
Natural wax coating Researchers from Aalto University (Finland; www.aalto.fi) have…
BUSINESS NEWSTECHNICAL & PRACTICALFEATURE REPORTFACTS AT YOUR FINGERTIPSTECHNOLOGY PROFILEENVIRONMENTAL MANAGEREQUIPMENT & SERVICESFOCUSNEW PRODUCTS + Show More

Comment PDF Processing & Handling

Chementator: Soy polymers may have a future in drug delivery  

By Gerald Ondrey |

Soy-oil-based hydrogels developed by the U.S. Agricultural Research Service (ARS) show promise as biodegradable encapsulants for drug delivery. Scientists at ARS’ National Center for Agricultural Utilization Research (Peoria, Ill.; edlinks.chemengonline.com/7373-539) have collaborated with researchers at the University of Toronto to encapsulate the breast-cancer drug doxorubicin in hydrogel nanoparticles. In drug-release experiments, the product proved eight times more toxic to cancerous cell lines than conventional lipid-water solutions of the drug. ARS makes the hydrogels by ring-opening polymerization of epoxidized soy oil in an organic solvent (for example, methylene dichloride or ethyl acetate), using a cationic catalyst, such as boron trifluoride. Sodium hydroxide solution is used to hydrolyze the polymers. Hydrogels, an aqueous solution containing 3 – 5% polymer, are formed by adjusting the pH, says Sevim Erhan, an ARS chemist. Nanoparticles are formed by subjecting the gel to ultrasound and drug-encapsulation is achieved by mixing the drug in the gel prior to ultrasonication. Originally, ARS set out to develop a renewable, biodegradable substitute for petroleum-derived polymers, such as polyacrylic acid and polyacrylamide,…
Related Content
A Bright Future for Quantum Dots
The novel performance characteristics and tunability of quantum dots make them a promising nanomaterial in numerous emerging applications Quantum dots…
A step closer for graphene-coated anodes
A new collaboration between PPG (Pittsburgh, Pa.; www.ppg.com), SiNode Systems (Chicago, Ill.; www.sinodesystems.com) and Raymor Industries (Boirsbriand, Que., Canada; www.raymor.com)…

Chemical Engineering publishes FREE eletters that bring our original content to our readers in an easily accessible email format about once a week.
Subscribe Now
Improving chemical production processes with IIoT and AI technologies
New filtration technology for highly corrosive media
PTA production: Lowering OPEX without compromising on quality
Sure that zero means zero in your zero-liquid discharge (ZLD) process?
How separation processes profit from Industrial Internet of Things (IIoT) solutions

View More

Live chat by BoldChat