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Chemical Engineering

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A single flow reactor produces a toxic precursor, an unstable reagent and product

| By Gerald Ondrey

The Vilsmeier reagent (VR), [(CH3)2 NCHCl]Cl, is necessary for producing a large range of pharmaceuticals, but it is unstable in air and is made from the toxic precursor phosgene (COCl2). A new flow-reactor system has been developed by Akihiko Tsuda,…