ID
× COMMENTARYCOVER STORYIN THE NEWSNEWSFRONTSCHEMENTATOR + Show More
Chemical Engineering MagazineCO2-to-methanol
Researchers from Penn State University (State College, Pa.; www.psu.edu) and…
Chemical Engineering MagazineChementator Briefs
Bio-isoprene Yokohama Rubber Co. (Tokyo, Japan; www.yokohama.com) has developed what…
BUSINESS NEWSTECHNICAL & PRACTICALFACTS AT YOUR FINGERTIPSTECHNOLOGY PROFILEENGINEERING PRACTICEENVIRONMENTAL MANAGEREQUIPMENT & SERVICESFOCUSNEW PRODUCTS + Show More SHOW PREVIEWS

Comment

Making PLGA by one-step fermentation

By Paul Grad |

A Korean team, headed by professor Sang Yup Lee of the Korea Advanced Institute of Science and Technology (Daejeon, South Korea; www.kaist.ac.kr), has obtained various forms of PLGA [poly(lactate-co-glycolate)] from natural sources, allowing plastics to be made in an environmentally friendly manner. PLGA is a copolymer of lactic and glycolic acid. It is biodegradable, biocompatible and non-toxic. It has been widely used for surgical sutures, prosthetic devices, and in drug delivery and tissue engineering. Up to now, PLGA has been synthesized by means of a catalytic ring-opening co-polymerization of two different monomers, the cyclic dimers (1,4-dioxane-2,5-diones) of glycolic acid and lactic acid. In contrast, the Korean team is able to biologically produce PLGA (and several novel copolymers) from renewable biomass by a one-step, direct fermentation by metabolically engineered Escherichia coli. Initially the researchers developed a method for producing PLGA in engineered E. coli. The process involved eliminating the genes responsible for byproducts formation and enhancing the expression of certain genes, thus achieving the effective production of certain target polymers. However, the team saw that it could not enhance the polymer…
Related Content
Facts at your Fingertips: Fermentation
For intermediate and specialty chemicals, the incorporation of biotechnology-based processes has become a viable option for the chemical process industries…
Commercial debut for a new PLA-production process
To reduce dependency on petroleum-based plastics, thyssenkrupp Industrial Solutions AG (Essen, Germany; www.thyssenkrupp-industrial-solutions.com) has developed a new manufacturing process for…

Chemical Engineering publishes FREE eletters that bring our original content to our readers in an easily accessible email format about once a week.
Subscribe Now
Simplify sensor handling and maintenance with ISM
Three reasons to measure pH in-line
ABB Ability™ technology to transform BASF rotating equipment into intelligent machinery and improve uptime and reliability
Detect and correct anomalies early in your batch processes
ABB at ACHEMA 2018

View More

Live chat by BoldChat