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Mechanochemistry performs cross-coupling reactions

By Tetsuo Satoh |

Palladium-catalyzed cross-coupling reactions are one of the most powerful and versatile methods to synthesize a wide range of complex functionalized molecules. However, the development of solid-state cross-coupling reactions remains extremely limited. Now, Hajime Itoh, Koji Kubota and colleagues at Hokkaido University (Sapporo, Japan; https://labs.eng.hokudai.ac.jp/labo/organoelement) reported a rational strategy that provides a general entry to palladium-catalyzed Buchwald-Hartwig cross-coupling reactions in the solid state. The key finding of this study is that olefin additives can act as efficient molecular dispersants for the palladium-based catalyst in solid-state media to facilitate solid-state cross-coupling. Their strategy could inspire the development of industrially attractive, solvent-free palladium-catalyzed cross-coupling processes for other valuable synthetic targets. Conventionally, palladium-catalyzed cross-coupling reactions of liquid and solid substrates are conducted in organic solvents. Researchers sought to re-design palladium-based catalyst systems for the solid state, which could potentially unlock versatile applications for solid-state synthesis. They have developed a rational strategy for a potentially general…
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