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Multi-state switchable stationary phase for chiral separation

By Tetsuo Satoh |

High-pressure liquid chromatography (HPLC) using a chiral stationary phase (CSP) is the most effective method for separating enantiomers of chiral molecules. However, the limited number of CSPs available puts a constraint on applying this technology universally. Now, researchers from the group of Katsuhiro Maeda at Kanazawa University (Kanazawa City, http://kohka.ch.t.kanazawa-u.ac.jp), in collaboration with the University of Santiago de Compostela, have Demonstration of new method for enantiomeric separations using HPLCDemonstration of new method for enantiomeric separations using HPLC with an optically active poly(phenylacetylene) derivative as the CSP. The helical conformation of the polymer can be controlled through changing the mixed state of left- or right-handed chiral conformations by introducing Na+ or Cs+ ions, respectively. This results in a switchable system that offers three different modes of recognition. The switchable CSP is based on a helical polymer material (diagram) containing a chiral pendant group that causes the polymer to adopt different conformations in response to metal ions. When Na+ ions are present, the polymer is forced to adopt a left-handed helix so that the ions can interact with the aromatic component…
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