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This product helps vaccine manufacturers reduce downstream processing costs

By Gerald Ondrey |

Biopharmaceutical companies — especially those involved in manufacturing vaccines — spend a lot of effort and money to remove host cell nucleic acid (DNA and RNA) impurities from fermentation batches. The total downstream processing costs can account for up to 80% of the total manufacturing cost, says Stefan Schoenert, head of strain and process development at c-LEcta GmbH (Leipzig, Germany; www.c-lecta.com). In addition, the purification processes should ideally be performed without using animal-derived products, he says. To help reduce the effort and costs associated with downstream processing, c-LEcta has developed an advanced nuclease product, tradenamed Denarase, which makes it easy to remove host cell DNA/RNA impurities from biological production processes. Denarase cleaves all forms of DNA and RNA (single-stranded, double-stranded, linear and circular) in an unspecified (sequence-independent) way, explains Schoenert. The enzyme product is active in all commonly used buffers in the presence of both ionic and nonionic surfactants, as well as many reducing and chaotropic agents. It is also long-term stable at room temperature. Unlike competitive nuclease products, which are usually produced using Escherichia coli as expression…
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