I D
× COMMENTARYCOVER STORYIN THE NEWSNEWSFRONTSCHEMENTATOR + Show More
Chemical Engineering MagazineChementator Briefs
Depolymerization Last month, DuPont Teijin Films Ltd. (DTF; Contern, Luxembourg;…
BUSINESS NEWSTECHNICAL & PRACTICALFEATURE REPORTFACTS AT YOUR FINGERTIPSTECHNOLOGY PROFILEENVIRONMENTAL MANAGEREQUIPMENT & SERVICESFOCUSNEW PRODUCTS + Show More SHOW PREVIEWS

Comment

Two new catalysts for continuous-flow synthesis

By Tetsuo Satoh |

Shu Kobayashi and colleagues at the University of Tokyo (Japan; www.chem.s.u-tokyo.ac.jp) reported on two new catalysts for synthesizing fine chemicals using their continuous-flow reactor system. The first technology is a novel methodology using CsF.Al2O3 as a highly efficient, environmentally benign, and reusable solid-base catalyst to synthesize glutamic acid derivatives by stereoselective 1,4-addition of glycine derivatives to α,β-unsaturated esters. CsF.Al2O3 (with 40 wt.% CsF and thermal treatment at 200°C under vacuum) showed not only great selectivity toward 1,4-addition reactions (94% after 38 h) by suppressing the undesired formation of pyrrolidine derivations by [3+2] cycloadditions (with 1,4:[3+2] = 99:1), but also offered high yields for the 1,4-adduct with excellent anti diastereoselectivities (with anti:syn better than 99:1). Continuous-flow synthesis (for more than 50 days) of 3-methyl glutamic acid derivative was successfully demonstrated by using this solid-base catalysis. They are expecting that the developed procedure will be applied for the various continuous flow fine synthesis of stereoselective catalytic reactions. The second technology is the hydrogenation of arenes, an important reaction not only for hydrogen…
Related Content

Chemical Engineering publishes FREE eletters that bring our original content to our readers in an easily accessible email format about once a week.
Subscribe Now
Reduce the Risk of Corrosion in Fertilizer Production
3 Reasons to Automate Sensor Cleaning
Protect Your Turbines from Silica with a Low Maintenance Analyzer
Your Off-line pH Measurements Might Be Misleading and Costing You a Lot of Money
Reduce Explosion Risk in 2 Seconds with In Situ Oxygen Analysis

View More

Live chat by BoldChat