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Addressing Pumping Issues in Biopharmaceutical Operations

By Glenn Hiroyasu and Sueli Roel Backes |

Quaternary diaphragm pumps deliver the low pulsation and shear that is critical to these biopharmaceutical and continuous-manufacturing operations Biopharmaceutical, pharmaceutical and nutraceutical manufacturing may come in a wide variety of forms, but every iteration of unit operation must adhere to an unbending set of operational parameters and structures if the desired outcome — a viable, contaminant-free drug suitable for human or animal administration — is to be realized. It is all about “controlled fluid transfer.” Three of the more common unit operations within the biopharmaceutical-manufacturing universe are chromatography, virus filtration and tangential flow filtration (TFF). In order for these unique operations to be implemented successfully, though, the operator must be aware of their specific operating characteristics. For example, chromatography requires constant fluid flowrates during their operations, but may have varying pumping pressures. Virus filtration, on the other hand, will feature constant pumping pressures, but flowrates will change as the filters become clogged or fouled. And in TFF, the main challenge is attempting to keep the flowrate and pressure unchanging throughout the process. All these…
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