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Comment Separation Processes

High-efficiency cell removal

By Scott Jenkins |

Acoustic wave separation (AWS) technology can improve cell-culture clarification in biopharmaceutical applications by enabling high-efficiency, continuous removal of cells in a closed system without centrifugation. Developed by FloDesign Sonics (Wilbraham, Mass.; www.flodesign.org) and licensed to Pall Corp. (Port Washington, N.Y.; www.pall.com), the AWS technology works by applying acoustic forces across a flow channel to generate a three-dimensional standing wave. When a cell culture passes through the flow channel, the cells are trapped at the nodes of the acoustic waves, and they aggregate and precipitate as their buoyancy decreases. AWS is capable of removing cells without any temperature increases or physical damage to the cells or proteins, Pall says. The technology can be used with Pall’s continuous bioprocessing and single-use products.
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